Bettschart & Kofler Kommunikationsberatung GmbH
Bettschart & Kofler Kommunikationsberatung GmbH
Dr. Birgit Kofler
Phone: +43 676 63 68 930
  • polyneuropathy risk
  • statins
  • EAN Congress
  • neurology
  • medical research
  • health
  • medicine
Tue, 27.06.2017
ptp20170627030 Health/Medicine, Science/Technology
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Statins not associated with increased polyneuropathy risk, Danish study says
Study presented at the 3rd Congress of the European Academy of Neurology

Amsterdam (ptp030/27.06.2017/13:00) - Here is a piece of good news for patients who rely on cholesterol-lowering medications. In a break from earlier assumptions, Danish researchers at the 3rd Congress of the European Academy of Neurology (EAN) in Amsterdam reported that the use of statins did not lead to a higher risk of developing polyneuropathy.

Polyneuropathy entails systemic damage to peripheral nerves with symptoms that often include pain, unpleasant physical sensations such as pins and needles, numbness, or distressing perceptions of coldness and heat in the limbs. Polyneuropathy may also result in weakness, e.g., in the hands and feet.

Until now, experts have debated whether statins could be a possible trigger for this nerve disorder. Several studies were unable to prove a connection while individual case reports and a study conducted in Denmark in 2002 cast doubt on this conclusion. The incidence of polyneuropathy of no known cause (i.e., idiopathic polyneuropathy) in this study was quite low, but the relative risk not insignificant nonetheless: Patients who suffered from polyneuropathies were 14 times more likely to have taken statins, compared with controls from the general population.

Now the Danish team of researchers led by Prof David Gaist drilled deeper on this question. The study was repeated with a design highly similar to that of the previous 2002 study, but this time a considerably larger data set was included spanning the years 1999 through 2013. After excluding patients with diabetes, high alcohol use and other recognized risk factors of polyneuropathy, a total of 370 patients with a definite diagnosis of polyneuropathy were identified. Use of statins among these patients with polyneuropathy of no known cause was compared with that of a control group of 7,400 individuals. In the end, the researchers were able to give the all clear signal.

Lead author, Dr Toke de Koning Svendsen from Odense University Hospital summarized the findings as follows. "In our study, there was no connection between the use of statins and the occurrence of polyneuropathies." The lack of an association to polyneuropathy was confirmed in analyses that took statin dose and duration of statin use into consideration. "One caveat we must add, however, is that we did not include patients with diabetes or other established risk factors of polyneuropathy in our study. So, even though the news is good, we wish to acknowledge this potential study limitation", added Dr Svendsen.

Source: 3rd EAN Congress Amsterdam 2017, Abstract Svendsen et al. Statins and polyneuropathy revisited: Case-control study in Denmark, 1999-2013

Submitter: Bettschart & Kofler Kommunikationsberatung GmbH
Contact: Dr. Birgit Kofler
Phone: +43 676 63 68 930
Bettschart & Kofler Kommunikationsberatung GmbH